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When prescribing an alternative class of glucose-lowering therapy, clinicians are advised to use medicines across the class evenly to mitigate the potential for further national shortages, the notification added

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The integration of all three pathways is proposed to create a complementary pharmacological profile: appetite suppression and improved insulin secretion from GLP-1 and GIP agonism, combined with enhanced energy expenditure and hepatic lipid metabolism from glucagon receptor activation