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Key takeaways: Rifamycin antibiotics, anti-HIV drugs, certain anti-seizure drugs, and some anti-fungal medications can all lower the effectiveness of some birth control methods You should avoid supplements made from St Johns wort and be cautious using activated charcoal if youre on the pill You dont need to take supplements while youre on birth control unless you have a deficiency On this page Have you ever wondered why your doctor asks about medications youre taking when youre there for a birth control prescription