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Isolated tumors from GAN DIO-NASH-HCC mice demonstrated an extensive number of differentially expressed genes (DEGs) compared to corresponding adjacent non-tumorous (ANT) liver tissue samples (1249 DEGs) as well as compared to healthy liver samples from chow-fed controls (8637 DEGs)

Therefore, researchers have begun to explore the potential mechanisms of tumor drug resistance with the aim of improving the efficacy of chemotherapy

A sample microdosing schedule might include: Start: 0.125 mg once per week Increase to 0.25 mg after 2-4 weeks if well tolerated Optional gradual titration to 0.5 mg weekly if needed and tolerated Some patients experience excellent benefits while remaining at lower doses long-term

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