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Invest New Drugs 31(2):333344 Ming Z, Wotton CA, Appleton RT, Ching JC, Loewen ME, Sawicki G et al (2015) Systemic lipopolysaccharide-mediated alteration of cortical neuromodulation involves increases in monoamine oxidase-a and acetylcholinesterase activity

doi: 10.1159/000485895

1 The Components of Each CYANOKIT Each CYANOKIT consists of 1 : Dosing and Administration for CYANOKIT Recommended Dosing for CYANOKIT 1 The starting dose of CYANOKIT for adults is 5 g (contained in a single vial), administered by IV infusion over 15 minutes (approximately 15 mL/min)* Depending upon the severity of the poisoning and the clinical response, a second dose of 5 g may be administered by IV infusion up to a total dose of 10 g The rate of infusion for a potential second dose may range from 15 minutes (for patients in extremis) to 2 hours, as clinically indicated *No safety and efficacy studies have been performed in pediatric patients

An intermediate goal has been to develop vaccines against a subset of these viruses, referred to as broadly protective coronavirus vaccines rather than pan- or universal vaccines