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MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice

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Principles of insulin titration by regimen 1 Basal (intermediate- or long-acting insulin): Adjust the dose based on previous average fasting glucose levels Premixed insulin at breakfast and dinner: Adjust the breakfast dose based on average previous dinner readings (as long as a dose increase does not cause hypoglycaemia at lunchtime) Adjust the dinner dose based on previous average fasting glucose levels (as long as a dose increase does not cause hypoglycaemia at bedtime) Basalbolus:* Adjust the dose at mealtime based on the previous days glucose level measured either two hours after the corresponding mealtime or before the next mealtime (eg adjust the breakfast dose based on the previous 23 days average two-hour post-breakfast value or the pre-lunch value) *Rapid- or short-acting insulin is used for bolus dose