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Tributyrin Attenuates Metabolic and Inflammatory Changes Associated With Obesity Through a GPR109A-Dependent Mechanism

Elimination occurs primarily through renal clearance, with a plasma half-life of approximately 2-4 hours in rodent models

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In PA treated LO2 and HepG2 cells, administration of Ex-4 dramatically stimulated the expression of PPAR and its target gene CPT1a, and inhibited the expression of ACC (Figure 3E,F)