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Semaglutide is changing the landscape of obesity - and alternatives are on the way., external Prof O'Rahilly says that even if we solve the societal causes of obesity "there will be obese people and they will become ill", so he thinks the drugs will move us to a world of treating obesity "properly as a medical condition"

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MS-based proteomics For proteomics, extracted and immunoprecipitated proteins from the cecum, liver, and brain were separated on a Bolt 412% Bis-Tris Plus gel (Life Technologies Corporation - Thermo Fisher Scientific Inc., Waltham, MA, USA) for in-gel digestion