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The magnitude of IGF-1 increase varies by dose, duration, and individual responsiveness but is a reproducible finding across clinical practice and the smaller body of formal studies

JAMA Intern Med (2015) 175:151826

The honest answer is almost always the same: the medication works as prescribed, and most supplement stacking introduces cost and complexity without measurable benefit

The mechanism is thought to involve binding of the peptide C terminus to the receptor extracellular domain, followed by insertion of the peptide N terminus into the pocket formed by the transmembrane helices and extracellular loops, instigating receptor activation and signalling 19