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Interestingly, structure of an inhibitor of ACh esterase, acotiamide (brand name acofide), approved in Japan as a prokinetic motility drug against functional dyspepsia (216218), combines the two heterocycles, one of them thiazole, that may be considered as structural mimics of the thiazolium and aminopyrimidine heterocycles of thiamine

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doi: 10.1371/journal.pbio.1002135 3 BakerD

Reduces the Symptoms of Parkinsons Disease Parkinsons disease is a well-known neurodegenerative disease with symptoms like motor function loss and cognitive decline, and the second most common neurodegenerative disease in the world