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FIGURE 6 3.3.1 Curcumins function in microRNA control Curcumin influences the transcription and stability of miRNAs by upregulating tumor-suppressive miRNAs and downregulating oncomiRs, alters the expression of lncRNAs such as Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) and Urothelial Carcinoma-Associated 1(UCA1), and modifies the networks of circRNAs, specifically the miRNA sponging axes

Signs suggesting adequate treatment include plateau in improvement for two or more weeks, significant resolution of primary concerns, and strong improvement maintained during previous breaks

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