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In some embodiments, the otic formulation or composition comprises about 3% by weight of the cholesterol

doi: 10.3389/fphar.2025.1551843 Received 26 December 2024 Accepted 09 June 2025 Published 02 July 2025 Volume 16 - 2025 Edited by Ting Shen, Yangzhou University, China Reviewed by Shuo Yuan, University of Virginia, United States Yan Hu, Second Affiliated Hospital of Dalian Medical University, China Updates Copyright 2025 Mao, Huang, Li, Sun, Zhang, Cheng, Zeng, Lei, Wang and Yao

approximately one-third lost 20% or more

Regular use of copper peptides delivers visible improvements such as: Smoother texture and fewer fine lines Improved firmness and elasticity Reduced redness and more balanced tone Enhanced hydration and resilient barrier Most users notice a soft glow within 48 weeks, with deeper collagen and elastin improvements by 12 weeks