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And NLRP3 inhibitors can significantly improve proteinuria and renal function in mice, underscoring the importance of the NLRP3 inflammasome in kidney disease [183, 184]

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Matthews DR, Paldnius PM, Proot P et al (2019) Glycaemic durability of an early combination therapy with vildagliptin and metformin versus sequential metformin monotherapy in newly diagnosed type 2 diabetes (VERIFY): a 5-year, multicentre, randomised, double-blind trial

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In addition, HDL removes lipid hydroperoxides from LDL particles (846)

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