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After absorption, B12 is bound to transport proteins, 7580% to haptocorrin, which transports B12 in the blood, and 2025% to transcobalamin, which delivers B12 to the tissues, also referred to as active B12 or holo-transcobalamin

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Collectively, a dysregulated MGBA can promote neurodegeneration via multiple converging mechanisms: chronic peripheral and central inflammation, impaired barrier and metabolic support for the brain, accelerated protein misfolding, and diminished neuroprotective signaling