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Consistent with the intent of an evidence-mapping scoping review, studies were selected based on translational relevance to musculoskeletal tissue healing, orthopaedic care, and perioperative decision-making

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Some users report losing five times more body fat than average when combined with lifestyle changes

The original 2015 Cell Metabolism study demonstrated that intraperitoneal MOTS-c injections (5 mg/kg) in mice fed a high-fat diet prevented obesity and insulin resistance, with effects on fat mass, fasting glucose, and insulin sensitivity that rivaled pharmaceutical intervention [1]