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Subgroup results were directionally consistent among other age-specific subgroups of patients with BBS, including patients aged less than 18 years and greater than or equal to 18 years

Cell Signaling Technology, Danvers, MA) was used and staining was performed on the Benchmark Ultra-automated Stainer (Ventana) using diaminobenzidine as the chromogen

Important Considerations: Side Effects: Potential minor side effects include nausea and transient facial flushing

Renal impairment Mild to moderate renal impairment does not require dose adjustments, as tirzepatide is primarily metabolized through peptidase degradation rather than renal elimination