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KEY TAKEAWAYS Protein is non-negotiable: 80-100g daily prevents muscle loss (every successful participant hit this target) Cold foods during weeks 6-8: 35-40% reduction in nausea compared to hot meals Small frequent meals: Every 3 hours prevents blood sugar crashes and manages appetite suppression Gallbladder protection: 30-50g healthy fats daily reduces gallstone risk by 40% Hydration schedule: 64-80oz water daily, sipped between meals (not with meals) Phase-based approach: What works in week 1 fails in week 7

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Importantly, treatment with retatrutide not only resulted in robust weight reduction, but also in clear improvements in assessed cardiometabolic health measures