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Various chemical modifications such as PEGylation, glycosylation, and lipidation have enhanced its stability and bioavailability to safeguard catalase from enzymatic degradation and immune recognition

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Patients taking Mounjaro should also seek urgent medical advice if they develop sudden severe, persistent abdominal pain (which may radiate to the back and be accompanied by vomiting), as this could indicate acute pancreatitisa rare but serious adverse effect of GLP-1 receptor agonists including tirzepatide