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*Correspondence: Smita Kumar, [email protected] This article was submitted to Plant Traffic and Transport, a section of the journal Frontiers in Plant Science Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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GLP-1 Receptor Activation: Suppresses appetite through hypothalamic pathways Slows gastric emptying Enhances insulin secretion GIP Receptor Activation: Amplifies GLP-1 satiety effects Improves insulin sensitivity May directly affect fat cell metabolism Glucagon Receptor Activation: Increases energy expenditure (metabolic rate) Promotes fat breakdown (lipolysis) May prevent metabolic adaptation The Advantage: Single molecule means simpler manufacturing, potentially easier regulatory approval, and all three pathways activated with every dose

10.1016/j.tifs.2021.01.030 Trends Food Sci Technol