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However, as explained by the Alzheimers Drug Discovery Foundation in 2024, while urolithin A does have an impressive safety profile, its long-term safety has yet to be established.4 Also, while rare, some people can be allergic to pomegranates, which are rich in the polyphenols that are metabolized into urolithin A.21 This doesnt necessarily mean that those with pomegranate allergies will have a reaction to urolithin A supplements, but it could be something to keep in mind

It will not bind to GIP or GLP-1 receptors

Yes, certain fiber supplements and gentle laxatives are generally considered safe to use while taking GLP-1s, but you should always talk to your doctor first

PMID 25074540