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A comprehensive medical evaluation should include baseline blood pressure readings, current antihypertensive regimen, cardiovascular history, and kidney function tests

9.6%).21 A meta-analysis of 16 RCTs of orlistat 120 mg 3 times daily ( n = 10 631 participants) reported a mean placebo-subtracted weight change of 2.9% (95% CI 3.4% to 2.5%) at 1 year.53 The most common adverse effects with orlistat included oily stool, fecal urgency, and spotting, occurring in 15%30% of patients and leading to discontinuation in some cases.53 Further details on efficacy, potential adverse effects, contraindications, and potential medication interactions are available in Appendix 1, and are reviewed in greater detail in the full guideline on the Obesity Canada website.7 Long-term treatment After weight loss with pharmacotherapy Obesity medications are intended as part of a long-term treatment strategy (Table 1, recommendation 4)

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