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Medical teams might adjust other diabetic medications to prevent low blood sugar events

Hematoxylin and eosin (HE) staining was conducted according to routine protocols 49

Clinical trials indicate that participants lost an average of 20.9% of their body weight

Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (e.g., carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (e.g., acute congestive heart failure), excessive alcohol intake, hepatic impairment, and mitochondrial diseases [see Warnings and Precautions (5.1)]