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Data availability statement All papers included in the meta-analysis and systematic review are listed with additional information in Supplementary Material S1, and online with options to filter the database ( Data used for the meta-analysis was derived from papers cited in the reference section and contacting respective authors

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GPCRs can form dimers and oligomers both with themselves and with other GPCRs, suggesting the existence of mechanisms whereby one receptor can influence the function of another, a concept known as receptor crosstalk ( FIGURE 1 Multiple previous studies have shown that incretin receptors can form heterodimers, as demonstrated, for example, using bioluminescence resonance energy transfer (BRET) (Schelshorn et al., 2012