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Pregnancy Neonatal Opioid Withdrawal Syndrome Inform female patients of reproductive potential that use of oxycodone and acetaminophen tablets for an extended period of time during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated [see WARNINGS, PRECAUTIONS, Pregnancy] Embryo-Fetal Toxicity Inform female patients of reproductive potential that oxycodone and acetaminophen tablets can cause fetal harm and to inform the healthcare provider of a known or suspected pregnancy [see PRECAUTIONS

Hemodynamic impairment of blood pressure and stroke mechanisms in symptomatic intracranial atherosclerotic stenosis

doi: 10.1016/j.clnu.2014.04.019, 83

Volume reduction is typically necessary