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Researchers are examining whether altered NNMT activity affects nicotinamide metabolism, NAD-related pathways, methyl-donor balance and selected metabolic processes

These may include: ( 4 ) Fatigue or lack of energy Brain fog or trouble concentrating Irritability or mood swings Pale skin or shortness of breath Tingling in the hands and feet Difficulty walking or staggering Anemia Swollen or inflamed tongue A B12 deficiency in men may also contribute to low testosterone, weight gain, and poor exercise recoverymaking it a hidden factor in many mens health concerns