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Interestingly, allopurinol, which is a structural isomer of Hx and is an inhibitor of the Xan oxidase, can improve SZ symptoms either when given alone or as add-on medication to haloperidol ( leading to the formation of UA ( Statements Acknowledgments This review is based upon work supported in part by the grants from the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory R&D [Merit Reviews (Jeffrey K