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These local effects typically resolve rapidly and rarely require intervention beyond injection site rotation

However, aging, pollution, stress, and poor lifestyles can cause a depletion of these natural levels

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity

Risks and Unknowns Remaining research gaps include: Long-term systemic administration data Optimal dosing strategies outside dermatology Interaction with copper metabolism disorders Comparative efficacy versus standard wound treatments Most evidence supports local, tissue specific effects rather than systemic transformation