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Danuglipron (dosed twice daily) and orforglipron (once daily) continue in clinical trials, while the clinical development of lotiglipron (once daily) was recently stopped due to elevated transaminase liver enzymes

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When contextualized with FAERS disproportionality signals and the case series of severe hyposalivation, these mechanisms suggest that semaglutide may disrupt the rhythmic Ca 2+ cAMP dynamics required for normal secretion