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Deficiency of B12 can lead to a range of health issues, including anemia, neurological disorders, and DNA synthesis impairment

Mitochondria are the powerhouses of immunity

Another study also demonstrated that lactate, produced under hypoxic conditions in colorectal cancer (CRC), promotes the lactylation of H3K18, which in turn induces the transcription of autophagy enhancer protein RUBCNL, then promotes the maturation of autophagosomes, and mediates the recruitment of class III phosphatidylinositol 3-kinase(PI3K) complexes, thereby promoting tumor proliferation and mediating tumor resistance to bevacizumab [33]