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6 In the EXAMINE trial, a safety signal for increased risk of hospitalisation for heart failure was identified with alogliptin, particularly in people with a history of heart failure

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Animal studies found significantly fewer GABAergic neurons in the hypothalamus.[ref] Further animal research points directly to an increase in GABA-B receptors, which clear out GABA from the synapse and shift towards less GABA available.[ref] Injecting GABA directly into the central nervous system (animal studies again) reduces blood pressure.[ref] Circadian Rhythm and GABA: The area of the brain known as the suprachiasmatic nucleus (SCN) is where the bodys core circadian clock is centered