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For persistent or severe constipation lasting more than 3 weeks despite hydration, fiber, and over-the-counter measures, your doctor may recommend prescription-strength options like linaclotide or lubiprostone, which increase intestinal fluid secretion and motility

For instance, a recent study demonstrated the efficacy of the engineered GLP-1R/LepR dual agonist in reducing food intake and body weight in rodent models ( 17 )

Vegetarian or vegan diet (low in natural B12 sources)

however, its reputation as an anti-infective vitamin appears well founded, with dietary vitamin A supplementation reducing morbidity and mortality in patients with measles, infantile diarrhoea, malaria, and hand, foot and mouth disease (Dopali et al, 2021)