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Ultimately, the result suggests that palmitoyl-L-carnitine could be a novel therapeutic target for treating neurodegenerative diseases including AD

Histone modifiers are also dysregulated: histone deacetylases (HDAC1-3, SIRT1), methyltransferases (EZH2, MLL1), and demethylases (LSD1) alter chromatin states, contributing to progesterone resistance, inflammation, and fibrosis

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23 Patients with small patches of plaques may be hard to treat with systemic therapy alone but can be treated successfully when FAE is combined with another therapy such as phototherapy, topical, or other systemic drugs