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Conclusions and Recommendations Key messages for at-risk populations: The EVOKE trial failure does not invalidate GLP-1 agonists for preventionthe epidemiological signal remains strong, and these drugs may provide metabolic and cardiovascular benefits with potential cognitive co-benefits when used for approved indications SS-31s approval establishes precedent for mitochondrial-targeted therapeuticswatch this space for expanded indications Popular biohacker peptides (BPC-157, Dihexa, P21) have essentially no human cognitive evidence

Anyone with fatigue, dietary restrictions (like vegans), or low B12 levels from poor absorption can benefit

Jones SR, Gainetdinov RR, Jaber M, Giros B, Wightman RM, Caron MG