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Answer: Cagrilintide is a long-acting, synthetic amylin analog peptide that activates amylin receptors in the brain and pancreatic axis to produce sustained appetite suppression, given as a once-weekly subcutaneous injection with gradual dose titration

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The mechanism involves both GLP-1 and GIP signaling in brain regions that regulate reward and appetite, creating a fundamental shift in how the brain processes food-related stimuli

Microdosing protocols typically involve splitting the weekly dose into two or more smaller injections spread across the week