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This data can be accessible at: Abbreviations ADA: American Diabetes Association ALP: Alkaline phosphatase BMC: Bone mineral content BMD: Bone mineral density CDC: Centers for Disease Control and Prevention DAVID: Database for Annotation, Visualization and Integrated Discovery DXA: Dual-energy X-ray absorptiometry FAD: Flavin adenine dinucleotide FMN: Flavin mononucleotide GO: Gene Ontology GSH: Reduced glutathione GSSG: Oxidized glutathione KEGG: Kyoto Encyclopedia of Genes and Genomes MEC: Mobile Examination Center MET: Metabolic equivalent task NHANES: National Health and Nutrition Examination Survey PA: Physical activity PPIs: Protein-protein interactions RCS: Restricted cubic spline References Ensrud KE, Crandall CJ, Osteoporosis

This triple mechanism provides complementary metabolic effects: GLP-1R activation suppresses appetite and enhances glucose-dependent insulin secretion

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SOD3 was upregulated in the serum and placenta of physically active pregnant women [76]