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Additionally, they attenuate mammalian target of rapamycin (mTOR) activity through the inhibition of AKT-mediated prolin-rich akt substrate (PRAS40) phosphorylation, indicating that GLP-1R agonists (GLP-1RAs) help to control inflammation and immune responses in hCASMCs, improve vascular health, and may positively impact the treatment of atherosclerosis by modulating the AKT and mTOR signaling pathways (Li BY

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Patients who understand the biomechanical and inflammatory underpinnings of OA are more likely to engage consistently with lifestyle modifications (Moseng et al., 2024)

This integration enables LC-MS to analyze both known and previously unidentified carnitines with enhanced accuracy and reproducibility