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Medications with short half-lives may need to be taken several times a day

Studies comparing semaglutide to testosterone replacement therapy found that both treatments resulted in significant increases in total testosterone

Brent James, M.D., an expert on clinical quality improvement and patient safety, told Fierce Healthcare in an email that medicine has a long history of overreacting to a new drug and then quietly moving on when the full set of circumstances become known

Consequently, maintaining the therapeutic effects of GLP-1R agonism requires a long-term dosing regimen, much like medications used for other chronic conditions, such as statins for cholesterol control, ACE inhibitors and beta-blockers for blood pressure, or warfarin for blood thinning