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Taking these facts into consideration, the Food and Drug Administration (FDA) recommended that in order to establish the safety of a new antidiabetic therapy for T2DM, the manufacturers or sponsors should demonstrate that the new drug will not result in an unacceptable increase in cardiovascular risk and the trials population should also include high risk patients

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Implications for treatment selection As combination products become more common, the distinction between insulin and GLP-1 therapy becomes more important, not less

High-energy diets were also suggested to increase the metabolic burden on chickens, potentially altering energy allocation