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While the mechanism of this dermal invasion by MCs remains open, it has been proposed that the migration of hyperactive MCs into the dermis leads to the constant hyperpigmentation in melasma (Phansuk et al, 2022

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Importantly, metformin treatment in vivo in 3Tg-AD mice corrects the impaired aPKC-CBP pathway to repress Mgll expression, significantly rescuing impaired adult neurogenesis, preventing spatial memory decline, and reducing A accumulation