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The big difference here is that cancer research, for example, deals with end of life situations, and any such research can take on higher risks than when dealing with perfectly healthy subjects

Conversely, there was a correlation between poor adherence to the Mediterranean diet and greater urine trimethylamine oxide, a marker of enhanced cardiovascular risk (39)

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9 Although a few drugs have exhibited efficacy in the management of fibromyalgia symptoms, the outcomes are limited with only a proportion of patients experiencing a partial reduction of symptom severity, often only marginally better than placebo