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doi: 10.1038/s41392-024-01931-z, Summary Keywords central nervous system, feeding behavior, GLP-1 receptor agonists, gutbrain axis, obesity Citation OConnor RM (2026) Revisiting food addiction in the era of GLP-1based obesity pharmacotherapy via neural reward pathways linking feeding and substance use

While we didnt see phase 3 insulin sensitivity data, its clear that it profoundly reduces that just based on phase 2 data

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Retatrutide was being dosed at maximum strength from the start in Phase 2, while Phase 3 protocols use a slower escalation that typically reduces side effects and discontinuation