The bioavailability of food folate is estimated to be around 50%, i.e., half that of folic acid taken with water on an empty stomach, due to losses during digestion and absorption
While the standard regimen is a weekly injection, the exact frequency can be adjusted based on individual progress and any side effects experienced
This circumstance is likely to be favored in the brain parenchyma given its high metabolic rate and elevated oxygen consumption, which inevitably will produce significant amounts of reactive oxygen species as by-products, including the highly reactive superoxide anion O 2 that is converted to H 2 O 2 (Drge, 2 O 2 produce iron(III) and generate the highly reactive hydroxyl radical OH at the expense of endogenous reducing agents, i.e., polyunsaturated fatty acids like DHA or arachidonic acid, generating lipoperoxyl radicals
Some Canadian patients use Ozempic off-label for weight management at the lower price, but coverage and dosing limits differ - that decision belongs with the prescriber
