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With a variety of metal ions that could bind competitively with the chelator (e.g., calcium, magnesium, zinc, copper, manganese, and other metals, that typically exceed concentrations of toxic elements), the identity of the metal predominately bound by a chelating agent depends both upon accessibility of the chelator to the tissues, how strongly the metal is already bound in the tissues, how strongly the metal binds to the chelator, and to some extent the relative quantities of various ions [1]

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Preferred surface modifiers include nonionic and ionic surfactants

5) Allergies & Rubbing Allergies cause inflammation and frequent rubbing, which damages delicate skin and deepens pigmentation