Finally, because autoimmune diseases often require long-term medication and are subject to clear limitations related to systemic toxicity, new delivery approaches, such as local sustained-release systems and nanocarriers, are more suitable as amplifiers and safety valves for amino acid metabolism interventions, enabling the shaping of more favorable macrophage phenotypes within target tissues while reducing the risk of systemic exposure
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Synergistic peptide protocols: Exploration of combined use with ghrelin mimetics (GH secretagogues like GHRP or Ipamorelin) to compare or augment GH release through dual GHRH and ghrelin receptor activation