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Glossary 4-HNE 4-Hydroxynonenal AA-PE Arachidonic acid-phosphatidylethanolamine ACC Acetyl-CoA carboxylase ACSL1 Acyl-CoA synthetase long-chain family member 1 ACSL4 Acyl-CoA synthetase long-chain family member 4 AdA-PE Adrenic acid-phosphatidylethanolamine AHA American Heart Association AKI Acute kidney injury ALOX15 Arachidonate 15-lipoxygenase ALR Augmenter of liver regeneration AMPK AMP-activated protein kinase ATF4 Activating transcription factor 4 ATP Adenosine triphosphate AUC Area under the curve -HB -Hydroxybutyrate CaMKK2 Ca 2+ /calmodulin-dependent protein kinase kinase 2 CHOP C/EBP homologous protein CKD Chronic kidney disease Col1a1 Collagen type I alpha 1 CPT1A Carnitine palmitoyltransferase 1A DAMPs Damage-associated molecular patterns DHODH Dihydroorotate dehydrogenase DKD Diabetic kidney disease DMT1 Divalent metal transporter 1 DNL De novo lipogenesis eGFR Estimated glomerular filtration rate eIF2 Eukaryotic initiation factor 2 alpha EMT Epithelial-mesenchymal transition ESKD End-stage kidney disease euDKA Euglycemic diabetic ketoacidosis EZH2 Enhancer of zeste homolog 2 FAO Fatty acid -oxidation FA S Fatty acid synthase FOXA1 Forkhead box A1 FPN1 Ferroportin 1 FSP1 Ferroptosis suppressor protein 1 FTH1 Ferritin heavy chain 1 GBD Global Burden of Disease GCLM Glutamate-cysteine ligase modifier subunit GPX4 Glutathione peroxidase 4 GSH Glutathione HIF-1 Hypoxia-inducible factor 1 alpha HK-2 Human kidney-2 HMOX1 Heme oxygenase 1 (protein: HO-1) Hrd1 HMG-CoA reductase degradation protein 1 IDF International Diabetes Federation IL-6 Interleukin 6 LPCAT3 Lysophosphatidylcholine acyltransferase 3 MDA Malondialdehyde NCOA4 Nuclear receptor coactivator 4 NHANES National Health and Nutrition Examination Survey NLRP3 NOD-like receptor family pyrin domain containing 3 NOD Non-obese diabetic NRF2 Nuclear factor erythroid 2related factor 2 PANoptosis Pyroptosis apoptosis and necroptosis PERK Protein kinase RNA-like endoplasmic reticulum kinase PGC-1 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha PLOOH Phospholipid hydroperoxides PRMT6 Protein arginine methyltransferase 6 PUFA Polyunsaturated fatty acids PUFA-PE Polyunsaturated fatty acid-phosphatidylethanolamine RAS Reninangiotensin system ROS Reactive oxygen species SGLT1 Sodium-glucose cotransporter 1 SGLT2i Sodiumglucose cotransporter 2 inhibitors SLC3A2 Solute carrier family 3 member 2 SLC7A7 Solute carrier family 7 member 7 SLC7A11 Solute carrier family 7 member 11 SLC40A1 Solute carrier family 40 member 1 SREBP1c Sterol regulatory element-binding protein 1c STZ Streptozotocin T2DM Type 2 diabetes mellitus TFR1 Transferrin receptor 1 TGF Tubuloglomerular feedback UACR Urinary albumin-to-creatinine ratio XBP1 X-box binding protein 1 xCT Core subunit of System Xc- ZIP14 ZRT/IRT-like protein 14 -SMA Alpha-smooth muscle actin

The biggest advantage of an injection is that it delivers vitamin B12 directly into your system for full absorption

Tranexamic acid (topical): Investigated in clinical trials for melasma with more robust evidence than IV glutathione

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