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Description

the rationale is based on the fact that improved glycemia restores sensitivity to GIP [14, 16] and peptide engineering enables the design of hybrid ligands exhibiting dual agonism, as proved in experimental studies [19]

Beyond their well-established benefits in managing type 2 diabetes mellitus (T2DM) and promoting weight reduction, emerging evidence suggests that GLP-1 RAs may also offer neuroprotective, anti-inflammatory, and cardiovascular protective effects 4,5,6,7