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J Agr Food Sci 52:41924196 Zhang D, Xie P, Chen J, Dai M, Qiu T, Liang G (2009) Determination of microcystin-LR and its metabolites in snail ( Bellamya aeruginosa ), shrimp ( Macrobrachium nipponensis ) and silver carp ( Hypophthalmichthys molitrix ) from Lake Taihu, China

These results indicate that the dimer formation of GSTOs and CLICs is very important for their biological function

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In fact, the use of GSTP1 knockout mice demonstrated that loss of GSTP1 expression increases sensitivity to metabolic or environmental toxins and promotes mutations and cancer development ( FIGURE 2 Prostate cancer Promoter hypermethylation leading to epigenetic silencing of GSTP1 gene expression is frequently detected in prostate cancer cells, the most commonly diagnosed type of malignancy among men in Western European countries and the second cause of cancer-related deaths among men worldwide (Yang and Park, 2012