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Hall A, Karplus PA, Poole LB (2009) Typical 2-Cys peroxiredoxinsstructures, mechanisms and functions

Mechanistic studies have revealed that altered expression of iron metabolism-related proteins (including GPX4, FTH1, TfR1, and HO-1), accumulation of lipid peroxidation products, and disruption of antioxidant defense systems (particularly the Nrf2/GPX4 pathway) are central to ferroptosis progression in cardiac tissue

[] Interestingly, over the past decade, multiple case series and long-term data led to its reclassification into a malignant tumor

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