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It has been utilized in clinical trials to treat heart and kidney disease connected to hypertension and other chronic diseases by blocking MR signaling with MR antagonists (MRAs), which suppresses fibrosis in these organs as MRAs likely have cardio-protective effects by directly blocking cardiac and vascular MR (72, 73)

TUDCA reduces ER stress and neurodegeneration in HD, PD, and ALS models, 418 while 4-PBA improves motor function and reduces ER stress in AD, PD, and HD models

KPV can also support gut inflammation reduction , which is relevant because the gut-skin axis plays a documented role in atopic conditions

Cell death serves not only as a physiological mechanism controlling normal development and tissue balance, but also as a pathological process triggering organ dysfunction and causing local or systemic inflammation