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Oxidation of macromolecules is triggered by excess ROS, which in turn triggers cell death by releasing cytochrome c (Cyt-c) (82)

USA , 116 , 9433-9442, doi: Zhang, J., Pavlova, N

Intriguingly, breast cancer cells in metastatic lung tumors experience higher magnitude of solid stress compared to those in the primary tumor, underscoring the key role of the local microenvironment in modulating solid stress during cancer progression [116]