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For example, liraglutide and semaglutide have the attachments of fatty acid residues, which enable their reversible binding to albumin, while drugs such as dulaglutide and albiglutide are recombinant fusion proteins containing human immunoglobulin G or albumin chains [13]

Other genetic loci: Polymorphisms in genes such as CNR1, CTRB1/2 andTCF7L2, have shown associations with GLP-1RA response, particularly liraglutide, affecting glycemic control and metabolic parameters [14,133,135]

In conclusion, while compounded semaglutide and Ozempic share the same active ingredient, they are not identical

Hypersensitivity reactions anaphylactic reactions and angioedema have been reported